LongevityMap Gene
Gene details
- HGNC symbol
- RAPGEF4
- Aliases
- EPAC; CGEF2; EPAC2; EPAC; 2; Nbla00496; CAMP-GEFII
- Common name
- Rap guanine nucleotide exchange factor 4
- Description
- Cytogenetic Location
- 2q31.1
- UCSC Genome Browser
- View 2q31.1 on the UCSC genome browser
- OMIM
- 606058
- Ensembl
- ENSG00000091428
- UniProt/Swiss-Prot
- B7Z278_HUMAN
- Entrez Gene
- 11069
- UniGene
- 470646
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- RAPGEF4 (1 of many)
- Danio rerio
- rapgef4
- Drosophila melanogaster
- Epac
- Mus musculus
- Rapgef4
- Rattus norvegicus
- Rapgef4
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs6433379
- Reference