LongevityMap Gene

Gene details

HGNC symbol: RAD51B
Aliases: REC2; R51H2; RAD51L1
Common name: RAD51 paralog B
Description: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]
Cytogenetic Location: 14q24.1
UCSC Genome Browser: View 14q24.1 on the UCSC genome browser
OMIM: 602948
Ensembl: ENSG00000182185
UniProt/Swiss-Prot: A0A024R656_HUMAN
Entrez Gene: 5890
UniGene: 172587
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: rad-51
Danio rerio: rad51b
Mus musculus: Rad51b
Rattus norvegicus: Rad51b
Saccharomyces cerevisiae: RAD51

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RAD51

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

Reference