LongevityMap Gene
Gene details
- HGNC symbol
- POLRMT
- Aliases
- APOLMT; MTRNAP; MTRPOL; h-mtRPOL
- Common name
- RNA polymerase mitochondrial
- Description
- This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 19p13.3
- UCSC Genome Browser
- View 19p13.3 on the UCSC genome browser
- OMIM
- 601778
- Ensembl
- ENSG00000099821
- UniProt/Swiss-Prot
- Q4G0F4_HUMAN
- Entrez Gene
- 5442
- UniGene
- 254113
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rpom-1
- Danio rerio
- polrmt
- Drosophila melanogaster
- mtRNApol
- Mus musculus
- Polrmt
- Rattus norvegicus
- Polrmt
- Saccharomyces cerevisiae
- RPO41
- Schizosaccharomyces pombe
- rpo41
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RPO41
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs9304924
- Reference