LongevityMap Gene
Gene details
- HGNC symbol
- PLCB3
- Aliases
- Common name
- phospholipase C beta 3
- Description
- This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- Cytogenetic Location
- 11q13.1
- UCSC Genome Browser
- View 11q13.1 on the UCSC genome browser
- OMIM
- 600230
- Ensembl
- ENSG00000149782
- UniProt/Swiss-Prot
- PLCB3_HUMAN
- Entrez Gene
- 5331
- UniGene
- 523761
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs2244621
- Reference