LongevityMap Gene
Gene details
- HGNC symbol
- PIF1
- Aliases
- PIF; C15orf20
- Common name
- PIF1 5'-to-3' DNA helicase
- Description
- This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]
- Cytogenetic Location
- 15q22.31
- UCSC Genome Browser
- View 15q22.31 on the UCSC genome browser
- OMIM
- 610953
- Ensembl
- ENSG00000140451
- UniProt/Swiss-Prot
- PIF1_HUMAN
- Entrez Gene
- 80119
- UniGene
- 112160
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- pif-1
- Danio rerio
- pif1
- Drosophila melanogaster
- CG3238
- Mus musculus
- Pif1
- Rattus norvegicus
- Pif1
- Saccharomyces cerevisiae
- RRM3
- Saccharomyces cerevisiae
- PIF1
- Schizosaccharomyces pombe
- pif1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RRM3
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs3743046
- Reference