LongevityMap Gene
Gene details
- HGNC symbol
- PAX4
- Aliases
- KPD; MODY9
- Common name
- paired box 4
- Description
- This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 7q32.1
- UCSC Genome Browser
- View 7q32.1 on the UCSC genome browser
- OMIM
- 167413
- Ensembl
- ENSG00000106331
- UniProt/Swiss-Prot
- PAX4_HUMAN
- Entrez Gene
- 5078
- UniGene
- 129706
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- eyg-1
- Danio rerio
- pax4
- Drosophila melanogaster
- eyg
- Drosophila melanogaster
- toe
- Mus musculus
- Pax4
- Rattus norvegicus
- Pax4
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 diesase associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- PAX4 was associated with longevity (P = 0.008) after correcting for multiple hypothesis testing
- Indentifier
- rs327519
- Reference