LongevityMap Gene

Gene details

HGNC symbol: OGDH
Aliases: E1k; OGDC; AKGDH
Common name: oxoglutarate dehydrogenase
Description: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Cytogenetic Location: 7p13
UCSC Genome Browser: View 7p13 on the UCSC genome browser
OMIM: 613022
Ensembl: ENSG00000105953
UniProt/Swiss-Prot: A0A140VJQ5_HUMAN
Entrez Gene: 4967
UniGene: 488181
1000 Genomes: 1000 Genomes

GenAge model organism genes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs12155014

Reference