LongevityMap Gene

Gene details

HGNC symbol: NRXN3
Aliases: C14orf60
Common name: neurexin 3
Description: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
Cytogenetic Location: 14q24.3-q31.1
UCSC Genome Browser: View 14q24.3-q31.1 on the UCSC genome browser
OMIM: 600567
Ensembl: ENSG00000021645
UniProt/Swiss-Prot: A0A0U1RRJ0_HUMAN
Entrez Gene: 9369
UniGene: 368307
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: nrx-1
Danio rerio: nrxn3a
Danio rerio: nrxn3b
Drosophila melanogaster: Nrx-1
Mus musculus: Nrxn3

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as nrx-1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Dutch

Study Design

Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.

Conclusions

No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.

Indentifier

rs12892152

Reference