LongevityMap Gene
Gene details
- HGNC symbol
- MSMO1
- Aliases
- DESP4; ERG25; MCCPD; SC4MOL
- Common name
- methylsterol monooxygenase 1
- Description
- Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 4q32.3
- UCSC Genome Browser
- View 4q32.3 on the UCSC genome browser
- OMIM
- 607545
- Ensembl
- ENSG00000052802
- UniProt/Swiss-Prot
- MSMO1_HUMAN
- Entrez Gene
- 6307
- UniGene
- 105269
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- msmo1
- Mus musculus
- Msmo1
- Rattus norvegicus
- Msmo1
- Saccharomyces cerevisiae
- ERG25
- Schizosaccharomyces pombe
- erg25
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs1866218
- Reference