LongevityMap Gene
Gene details
- HGNC symbol
- MSI2
- Aliases
- MSI2H
- Common name
- musashi RNA binding protein 2
- Description
- This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
- Cytogenetic Location
- 17q22
- UCSC Genome Browser
- View 17q22 on the UCSC genome browser
- OMIM
- 607897
- Ensembl
- ENSG00000153944
- UniProt/Swiss-Prot
- B4DHE8_HUMAN
- Entrez Gene
- 124540
- UniGene
- 658922
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- msi-1
- Danio rerio
- msi2b
- Danio rerio
- msi2a
- Drosophila melanogaster
- Rbp6
- Mus musculus
- Msi2
- Rattus norvegicus
- Msi2
- Saccharomyces cerevisiae
- HRP1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs792376
- Reference