LongevityMap Gene
Gene details
- HGNC symbol
- MGP
- Aliases
- NTI; GIG36; MGLAP
- Common name
- matrix Gla protein
- Description
- This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
- Cytogenetic Location
- 12p12.3
- UCSC Genome Browser
- View 12p12.3 on the UCSC genome browser
- OMIM
- 154870
- Ensembl
- ENSG00000111341
- UniProt/Swiss-Prot
- A0A024RAX0_HUMAN
- Entrez Gene
- 4256
- UniGene
- 365706
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Mgp
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
- Indentifier
- rs1800802
- Reference