LongevityMap Gene
Gene details
- HGNC symbol
- MAVS
- Aliases
- IPS1; VISA; IPS-1; CARDIF
- Common name
- mitochondrial antiviral signaling protein
- Description
- This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- Cytogenetic Location
- 20p13
- UCSC Genome Browser
- View 20p13 on the UCSC genome browser
- OMIM
- 609676
- Ensembl
- ENSG00000088888
- UniProt/Swiss-Prot
- MAVS_HUMAN
- Entrez Gene
- 57506
- UniGene
- 570362
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs4815617
- Reference