LongevityMap Gene
Gene details
- HGNC symbol
- MAPKAP1
- Aliases
- MIP1; SIN1; JC310; SIN1b; SIN1g
- Common name
- mitogen-activated protein kinase associated protein 1
- Description
- This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 9q33.3
- UCSC Genome Browser
- View 9q33.3 on the UCSC genome browser
- OMIM
- 610558
- Ensembl
- ENSG00000119487
- UniProt/Swiss-Prot
- A0A024R863_HUMAN
- Entrez Gene
- 79109
- UniGene
- 495138
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- sinh-1
- Danio rerio
- mapkap1
- Drosophila melanogaster
- Sin1
- Mus musculus
- Mapkap1
- Rattus norvegicus
- Rn60_3_0143.1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as sinh-1
- GenAge microarray genes
- This gene is present as MAPKAP1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- MAPKAP1
- Reference