LongevityMap Gene
Gene details
- HGNC symbol
- MADD
- Aliases
- DENN; IG20; RAB3GEP
- Common name
- MAP kinase activating death domain
- Description
- Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11p11.2
- UCSC Genome Browser
- View 11p11.2 on the UCSC genome browser
- OMIM
- 603584
- Ensembl
- ENSG00000110514
- UniProt/Swiss-Prot
- A0A0A0MRB5_HUMAN
- Entrez Gene
- 8567
- UniGene
- 82548
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- aex-3
- Danio rerio
- madd
- Drosophila melanogaster
- Rab3-GEF
- Mus musculus
- Madd
- Rattus norvegicus
- Madd
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
- Conclusions
- Although no genome-wide associations were significant, mutiple SNPs and genes had suggestive associations with both age at death and morbidity-free survival at age 65 years
- Indentifier
- rs4752977
- Reference