LongevityMap Gene
Gene details
- HGNC symbol
- LAPTM5
- Aliases
- CLAST6
- Common name
- lysosomal protein transmembrane 5
- Description
- This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
- Cytogenetic Location
- 1p35.2
- UCSC Genome Browser
- View 1p35.2 on the UCSC genome browser
- OMIM
- 601476
- Ensembl
- ENSG00000162511
- UniProt/Swiss-Prot
- LAPM5_HUMAN
- Entrez Gene
- 7805
- UniGene
- 371021
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- CABZ01065103.1
- Mus musculus
- Laptm5
- Rattus norvegicus
- Laptm5
In other databases
- GenAge microarray genes
- This gene is present as LAPTM5
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs3795437
- Reference