LongevityMap Gene
Gene details
- HGNC symbol
- KIFC3
- Aliases
- Common name
- kinesin family member C3
- Description
- This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
- Cytogenetic Location
- 16q21
- UCSC Genome Browser
- View 16q21 on the UCSC genome browser
- OMIM
- 604535
- Ensembl
- ENSG00000140859
- UniProt/Swiss-Prot
- B7Z5U4_HUMAN
- Entrez Gene
- 3801
- UniGene
- 23131
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- klp-3
- Danio rerio
- kifc3
- Drosophila melanogaster
- ncd
- Mus musculus
- Kifc3
- Rattus norvegicus
- Kifc3
- Saccharomyces cerevisiae
- KAR3
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as KAR3
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs1582594
- Reference