LongevityMap Gene

Gene details

HGNC symbol
IL7 
Aliases
IL-7 
Common name
interleukin 7 
Description
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
Cytogenetic Location
8q21.13
UCSC Genome Browser
View 8q21.13 on the UCSC genome browser
OMIM
146660
Ensembl
ENSG00000104432
UniProt/Swiss-Prot
A0A0A0MTG5_HUMAN
Entrez Gene
3574
UniGene
591873
1000 Genomes
1000 Genomes

Homologs in model organisms

Mus musculus
Il7
Rattus norvegicus
Il7

In other databases

GenAge human genes
  • This gene is present as IL7

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
German
Study Design
Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
Conclusions
Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
Indentifier
rs2717536
Reference