LongevityMap Gene
Gene details
- HGNC symbol
- IL2
- Aliases
- IL-2; TCGF; lymphokine
- Common name
- interleukin 2
- Description
- The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 4q27
- UCSC Genome Browser
- View 4q27 on the UCSC genome browser
- OMIM
- 147680
- Ensembl
- ENSG00000109471
- UniProt/Swiss-Prot
- IL2_HUMAN
- Entrez Gene
- 3558
- UniGene
- 89679
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as IL2
Studies (3)
Significant/Non-significant: 0/3
Study 1
- Longevity Association
- Non-significant
- Population
- Irish
- Study Design
- 100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for -330 T/G SNP
- Conclusions
- No significant difference between centenarians and controls was observed
- Indentifier
- -330T/G
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Central and Southern)
- Study Design
- -330T/G SNP was examined in 168 centenarians and 214 control subjects matched for age and ancestry
- Conclusions
- No significant difference between centenarians and controls was observed
- Indentifier
- -330T/G
- Reference
Study 3
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs2069762
- Reference