LongevityMap Gene

Gene details

HGNC symbol
IL2 
Aliases
IL-2; TCGF; lymphokine 
Common name
interleukin 2 
Description
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
Cytogenetic Location
4q27
UCSC Genome Browser
View 4q27 on the UCSC genome browser
OMIM
147680
Ensembl
ENSG00000109471
UniProt/Swiss-Prot
IL2_HUMAN
Entrez Gene
3558
UniGene
89679
1000 Genomes
1000 Genomes

Homologs in model organisms

Mus musculus
Il2
Rattus norvegicus
Il2

In other databases

GenAge human genes
  • This gene is present as IL2

Studies (3)

Significant/Non-significant: 0/3

Study 1

Longevity Association
Non-significant
Population
Irish
Study Design
100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for -330 T/G SNP
Conclusions
No significant difference between centenarians and controls was observed
Indentifier
-330T/G
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Italian (Central and Southern)
    Study Design
    -330T/G SNP was examined in 168 centenarians and 214 control subjects matched for age and ancestry
    Conclusions
    No significant difference between centenarians and controls was observed
    Indentifier
    -330T/G
    Reference

      Study 3

      Longevity Association
      Non-significant
      Population
      Italian (Southern)
      Study Design
      A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
      Conclusions
      After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
      Indentifier
      rs2069762
      Reference