LongevityMap Gene

Gene details

HGNC symbol: IL1B
Aliases: IL-1; IL1F2; IL1-BETA
Common name: interleukin 1 beta
Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 2q14.1
UCSC Genome Browser: View 2q14.1 on the UCSC genome browser
OMIM: 147720
Ensembl: ENSG00000125538
UniProt/Swiss-Prot: IL1B_HUMAN
Entrez Gene: 3553
UniGene: 126256
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: il1b
Mus musculus: Il1b
Rattus norvegicus: Il1b

In other databases

GenAge microarray genes

This gene is present as IL1B

Studies (4)

Significant/Non-significant: 0/4

Study 1

Longevity Association

Non-significant

Population

Study Design

250 (52 males and 198 females) nonagenarians and 400 healthy control group blood donors (18-60 years old) were examined for +3953 and -511 SNPs

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Italian (Northern and Central)

Study Design

-511 C/T SNP was examined in 1131 unrelated individuals aged 20-102 years (453 females and 678 males, including 94 female and 40 male centenarians)

Conclusions

No significant differences in the genotype and allele frequency distributions were observed between young, elderly and centenarian subjects

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

-511 C/T SNP was evaluated with age or gender in 500 Japanese persons (mean age: 56.7 years old, range: 19-100)

Conclusions

No association with longevity was found

Indentifier

Reference

Study 4

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier