LongevityMap Gene

Gene details

HGNC symbol: IL1A
Aliases: IL1; IL-1A; IL1F1; IL1-ALPHA
Common name: interleukin 1 alpha
Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 2q14.1
UCSC Genome Browser: View 2q14.1 on the UCSC genome browser
OMIM: 147760
Ensembl: ENSG00000115008
UniProt/Swiss-Prot: IL1A_HUMAN
Entrez Gene: 3552
UniGene: 1722
1000 Genomes: 1000 Genomes

Homologs in model organisms

Mus musculus: Il1a
Rattus norvegicus: Il1a

In other databases

CellAge

This gene is present as IL1A

Studies (3)

Significant/Non-significant: 0/3

Study 1

Longevity Association

Non-significant

Population

Study Design

250 (52 males and 198 females) nonagenarians and 400 healthy control group (18-60 years old) were examined for -889 SNP

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Italian (Nothern and Central)

Study Design

The -889 C/T SNP was examined in 1131 unrelated individuals aged 20-102 years (453 females and 678 males, including 94 female and 40 male centenarians)

Conclusions

No significant differences in the genotype and allele frequency distributions were observed between young, elderly and centenarian subjects

Indentifier

Reference

Study 3

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier