LongevityMap Gene
Gene details
- HGNC symbol
- IL12RB2
- Aliases
- Common name
- interleukin 12 receptor subunit beta 2
- Description
- The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
- Cytogenetic Location
- 1p31.3
- UCSC Genome Browser
- View 1p31.3 on the UCSC genome browser
- OMIM
- 601642
- Ensembl
- ENSG00000081985
- UniProt/Swiss-Prot
- A0A0A0MTN7_HUMAN
- Entrez Gene
- 3595
- UniGene
- 479347
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
- Indentifier
- rs2030071
- Reference