LongevityMap Gene

Gene details

HGNC symbol
IGFBP4 
Aliases
BP-4; IBP4; IGFBP-4; HT29-IGFBP 
Common name
insulin like growth factor binding protein 4 
Description
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Cytogenetic Location
17q21.2
UCSC Genome Browser
View 17q21.2 on the UCSC genome browser
OMIM
146733
Ensembl
ENSG00000141753
UniProt/Swiss-Prot
A0A024R1U8_HUMAN
Entrez Gene
3487
UniGene
462998
1000 Genomes
1000 Genomes

Homologs in model organisms

Mus musculus
Igfbp4
Rattus norvegicus
Igfbp4

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
American (Caucasian)
Study Design
291 SNPs in 30 genes in the insulin/IGF1 signaling pathway were evaluated in 293 long-lived cases and 603 average-lifespan controls (all female), then replicated the candidate genes in two independent cohorts: 279 cases (47% male vs 797 controls(52.6% male) and 383 cases (25.2% male) vs 363 controls (42.7 % male)
Conclusions
Apart SNPs in FOXO3A and AKT1, no associations with longevity were significant after correcting for multiple testing, though SNPs in 7 other genes (FOXO1A, GHR, GHRHR, IGF1R, IGFBP3, IGFBP4, and PTEN) had suggestive significance
Indentifier
rs1009728
Reference