LongevityMap Gene
Gene details
- HGNC symbol
- IGF2BP1
- Aliases
- IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1
- Common name
- insulin like growth factor 2 mRNA binding protein 1
- Description
- This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
- Cytogenetic Location
- 17q21.32
- UCSC Genome Browser
- View 17q21.32 on the UCSC genome browser
- OMIM
- 608288
- Ensembl
- ENSG00000159217
- UniProt/Swiss-Prot
- IF2B1_HUMAN
- Entrez Gene
- 10642
- UniGene
- 144936
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- zbp-1
- Danio rerio
- igf2bp1
- Drosophila melanogaster
- Imp
- Mus musculus
- Igf2bp1
- Rattus norvegicus
- Igf2bp1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs1390154
- Reference