LongevityMap Gene

Gene details

HGNC symbol: IGF1
Aliases: MGF; IGFI; IGF-I
Common name: insulin like growth factor 1
Description: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Cytogenetic Location: 12q23.2
UCSC Genome Browser: View 12q23.2 on the UCSC genome browser
OMIM: 147440
Ensembl: ENSG00000017427
UniProt/Swiss-Prot: IGF1_HUMAN
Entrez Gene: 3479
UniGene: 160562
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: igf1
Mus musculus: Igf1
Rattus norvegicus: Igf1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Igf1

GenAge human genes

This gene is present as IGF1

GenAge microarray genes

This gene is present as IGF1

Studies (5)

Significant/Non-significant: 0/5

Study 1

Longevity Association

Non-significant

Population

Study Design

CA repeat (promoter) and CT repeat (intron 2) were examined in 1576 individuals aged >85

Conclusions

CA repeats (191 bp minor allele) seem to contribute most to female longevity, though this was not statistically significant

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Ashkenazi Jewish

Study Design

Genetic variation in IGF1 and IGF1R were examined in a cohort of Ashkenazi Jewish centenarians (286 females and 98 males, average age 97.7 years), their offspring (114 females and 174 males, mean age 67.8 years), and offspring-matched controls (n = 312, mean age 79.5 years)

Conclusions

No single variation was found in IGF1 gene

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

Association study in 493 elderly Han Chinese individuals (females = 94; males = 90) and 425 young individuals (controls)

Conclusions

No association between the microsatellite polymorphism and longevity was found. However, there were more male persons with 18/21 genotype in elderly group than that in control group (11.11 vs. 5.45%, p = 0.011), though the difference was not significant when corrected for multiple testing.

Indentifier

Reference

Study 4

Longevity Association: Non-significant
Population: Chinese (Han)
Study Design: 485 longevity subjects and 392 younger individuals were analyzed for the promoter region of the IGF-1 gene . By sequencing about 2.5 kb (kilo base pairs) upstream the transcription start site of exon 1 of the IGF-1 gene in 30 individuals from both groups respectively, 3 previously described SNPs (-439T/A (rs2288377), -541T/C (rs5742612) and -1246C/T (rs35767)) were acquired. Association was examined between these 3 SNPs and longevity by comparing the distribution of genotypes, alleles, and haplotypes in both the longevity and control groups.
Conclusions: None of the 3 SNP variants were found to be associated with longevity in the Han Chinese population.
Indentifier

Study 5

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier