LongevityMap Gene
Gene details
- HGNC symbol
- HMOX1
- Aliases
- HO-1; HSP32; HMOX1D; bK286B10
- Common name
- heme oxygenase 1
- Description
- Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 22q12.3
- UCSC Genome Browser
- View 22q12.3 on the UCSC genome browser
- OMIM
- 141250
- Ensembl
- ENSG00000100292
- UniProt/Swiss-Prot
- HMOX1_HUMAN
- Entrez Gene
- 3162
- UniGene
- 517581
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as HMOX1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Japanese
- Study Design
- A (GT)n repeat polymorphism in the promoter region of the human HO-1 gene was examined in younger (60 years, 59 male and 45 female) and older (60-75 years, 95 male and 106 female) subjects
- Conclusions
- The proportion of allelic frequencies in class L with a large size of (GT)n repeat, as well as the genotypic frequencies in group I with class L alleles, was significantly lower in the oldest male subjects than in the younger males. In contrast, in the oldest female subjects this was not observed.
- Indentifier
- (GT)n repeat
- Reference