LongevityMap Gene
Gene details
- HGNC symbol
- GSTA4
- Aliases
- GTA4; GSTA4-4
- Common name
- glutathione S-transferase alpha 4
- Description
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 6p12.2
- UCSC Genome Browser
- View 6p12.2 on the UCSC genome browser
- OMIM
- 605450
- Ensembl
- ENSG00000170899
- UniProt/Swiss-Prot
- A0A024RD58_HUMAN
- Entrez Gene
- 2941
- UniGene
- 485557
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- gst-13
- Caenorhabditis elegans
- gst-37
- Caenorhabditis elegans
- gst-26
- Caenorhabditis elegans
- gst-36
- Caenorhabditis elegans
- gst-9
- Caenorhabditis elegans
- gst-18
- Caenorhabditis elegans
- gst-5
- Caenorhabditis elegans
- gst-28
- Caenorhabditis elegans
- gst-29
- Caenorhabditis elegans
- gst-21
- Caenorhabditis elegans
- gst-35
- Caenorhabditis elegans
- gst-34
- Caenorhabditis elegans
- gst-30
- Caenorhabditis elegans
- gst-32
- Caenorhabditis elegans
- gst-39
- Caenorhabditis elegans
- gst-31
- Caenorhabditis elegans
- gst-6
- Caenorhabditis elegans
- gst-17
- Caenorhabditis elegans
- gst-27
- Caenorhabditis elegans
- gst-40
- Caenorhabditis elegans
- gst-3
- Caenorhabditis elegans
- gst-19
- Caenorhabditis elegans
- gst-16
- Caenorhabditis elegans
- gst-7
- Caenorhabditis elegans
- gst-20
- Caenorhabditis elegans
- gst-15
- Caenorhabditis elegans
- gst-2
- Caenorhabditis elegans
- gst-4
- Caenorhabditis elegans
- gst-12
- Caenorhabditis elegans
- gst-14
- Caenorhabditis elegans
- gst-38
- Caenorhabditis elegans
- gst-24
- Caenorhabditis elegans
- gst-8
- Caenorhabditis elegans
- gst-33
- Caenorhabditis elegans
- gst-22
- Danio rerio
- gsta.2
- Danio rerio
- gsta.1
- Danio rerio
- gsta.2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as gst-5
- GenAge human genes
- This gene is present as GSTA4
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs405729
- Reference