LongevityMap Gene
Gene details
- HGNC symbol
- GSTA3
- Aliases
- GTA3; GSTA3-3
- Common name
- glutathione S-transferase alpha 3
- Description
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 6p12.2
- UCSC Genome Browser
- View 6p12.2 on the UCSC genome browser
- OMIM
- 605449
- Ensembl
- ENSG00000174156
- UniProt/Swiss-Prot
- GSTA3_HUMAN
- Entrez Gene
- 2940
- UniGene
- 102484
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- gst-13
- Caenorhabditis elegans
- gst-37
- Caenorhabditis elegans
- gst-26
- Caenorhabditis elegans
- gst-36
- Caenorhabditis elegans
- gst-9
- Caenorhabditis elegans
- gst-15
- Caenorhabditis elegans
- gst-17
- Caenorhabditis elegans
- gst-5
- Caenorhabditis elegans
- gst-28
- Caenorhabditis elegans
- gst-29
- Caenorhabditis elegans
- gst-21
- Caenorhabditis elegans
- gst-35
- Caenorhabditis elegans
- gst-34
- Caenorhabditis elegans
- gst-30
- Caenorhabditis elegans
- gst-32
- Caenorhabditis elegans
- gst-39
- Caenorhabditis elegans
- gst-31
- Caenorhabditis elegans
- gst-14
- Caenorhabditis elegans
- gst-18
- Caenorhabditis elegans
- gst-19
- Caenorhabditis elegans
- gst-12
- Caenorhabditis elegans
- gst-40
- Caenorhabditis elegans
- gst-16
- Caenorhabditis elegans
- gst-20
- Caenorhabditis elegans
- gst-6
- Caenorhabditis elegans
- gst-7
- Caenorhabditis elegans
- gst-3
- Caenorhabditis elegans
- gst-27
- Caenorhabditis elegans
- gst-38
- Caenorhabditis elegans
- gst-2
- Caenorhabditis elegans
- gst-8
- Caenorhabditis elegans
- gst-24
- Caenorhabditis elegans
- gst-4
- Caenorhabditis elegans
- gst-22
- Caenorhabditis elegans
- gst-33
- Danio rerio
- gsta.2
- Danio rerio
- gsta.2
- Danio rerio
- gsta.1
- Mus musculus
- Gsta3
- Rattus norvegicus
- Gsta1
- Rattus norvegicus
- Gsta1
- Rattus norvegicus
- LOC501110
- Rattus norvegicus
- Gsta3
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as gst-5
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs3818234
- Reference