LongevityMap Gene
Gene details
- HGNC symbol
- GORASP2
- Aliases
- p59; GRS2; GOLPH6; GRASP55
- Common name
- golgi reassembly stacking protein 2
- Description
- This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
- Cytogenetic Location
- 2q31.1
- UCSC Genome Browser
- View 2q31.1 on the UCSC genome browser
- OMIM
- 608693
- Ensembl
- ENSG00000115806
- UniProt/Swiss-Prot
- GORS2_HUMAN
- Entrez Gene
- 26003
- UniGene
- 431317
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- Y42H9AR.1
- Danio rerio
- gorasp2
- Drosophila melanogaster
- Grasp65
- Mus musculus
- Gorasp2
- Rattus norvegicus
- LOC103690018
- Rattus norvegicus
- Gorasp2
- Saccharomyces cerevisiae
- GRH1
- Schizosaccharomyces pombe
- SPAC1D4.02c
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs4668356
- Reference