LongevityMap Gene

Gene details

HGNC symbol: FGD5
Aliases: ZFYVE23
Common name: FYVE, RhoGEF and PH domain containing 5
Description
Cytogenetic Location: 3p25.1
UCSC Genome Browser: View 3p25.1 on the UCSC genome browser
OMIM: 614788
Ensembl: ENSG00000154783
UniProt/Swiss-Prot: B7ZM68_HUMAN
Entrez Gene: 152273
UniGene: 412406
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: tag-52
Danio rerio: fgd5b
Danio rerio: fgd5a
Mus musculus: Fgd5
Rattus norvegicus: Fgd5

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

German

Study Design

Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).

Conclusions

Thirty-two SNPs previously associated with longevity were not associated with longevity in this study

Indentifier

rs294636

Reference