LongevityMap Gene
Gene details
- HGNC symbol
- CYC1
- Aliases
- UQCR4; MC3DN6
- Common name
- cytochrome c1
- Description
- This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
- Cytogenetic Location
- 8q24.3
- UCSC Genome Browser
- View 8q24.3 on the UCSC genome browser
- OMIM
- 123980
- Ensembl
- ENSG00000179091
- UniProt/Swiss-Prot
- CY1_HUMAN
- Entrez Gene
- 1537
- UniGene
- 289271
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- cyc-1
- Danio rerio
- cyc1
- Drosophila melanogaster
- CG4769
- Drosophila melanogaster
- CG14508
- Mus musculus
- Cyc1
- Rattus norvegicus
- Cyc1
- Saccharomyces cerevisiae
- CYT1
- Schizosaccharomyces pombe
- cyt1
In other databases
- GenAge model organism genes
- GenAge microarray genes
- This gene is present as CYC1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as CYT1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs11780874
- Reference