LongevityMap Gene
Gene details
- HGNC symbol
- CRTAC1
- Aliases
- ASPIC; ASPIC1; CEP-68
- Common name
- cartilage acidic protein 1
- Description
- This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
- Cytogenetic Location
- 10q24.2
- UCSC Genome Browser
- View 10q24.2 on the UCSC genome browser
- OMIM
- 606276
- Ensembl
- ENSG00000095713
- UniProt/Swiss-Prot
- CRAC1_HUMAN
- Entrez Gene
- 55118
- UniGene
- 500736
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
- Conclusions
- Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
- Indentifier
- rs508001
- Reference