LongevityMap Gene
Gene details
- HGNC symbol
- CDKN2C
- Aliases
- p18; INK4C; p18-INK4C
- Common name
- cyclin dependent kinase inhibitor 2C
- Description
- The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1p32.3
- UCSC Genome Browser
- View 1p32.3 on the UCSC genome browser
- OMIM
- 603369
- Ensembl
- ENSG00000123080
- UniProt/Swiss-Prot
- CDN2C_HUMAN
- Entrez Gene
- 1031
- UniGene
- 525324
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as CDKN2C
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- CDKN2C
- Reference