LongevityMap Gene
Gene details
- HGNC symbol
- CDK10
- Aliases
- PISSLRE
- Common name
- cyclin dependent kinase 10
- Description
- The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
- Cytogenetic Location
- 16q24.3
- UCSC Genome Browser
- View 16q24.3 on the UCSC genome browser
- OMIM
- 603464
- Ensembl
- ENSG00000185324
- UniProt/Swiss-Prot
- B7Z537_HUMAN
- Entrez Gene
- 8558
- UniGene
- 699177
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- cdk10
- Drosophila melanogaster
- cdc2rk
- Mus musculus
- Cdk10
- Rattus norvegicus
- Cdk10
- Saccharomyces cerevisiae
- CTK1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as CTK1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
- Indentifier
- rs2075880
- Reference