LongevityMap Gene
Gene details
- HGNC symbol
- BRIP1
- Aliases
- OF; BACH1; FANCJ
- Common name
- BRCA1 interacting protein C-terminal helicase 1
- Description
- The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q23.2
- UCSC Genome Browser
- View 17q23.2 on the UCSC genome browser
- OMIM
- 605882
- Ensembl
- ENSG00000136492
- UniProt/Swiss-Prot
- A0A024QZ45_HUMAN
- Entrez Gene
- 83990
- UniGene
- 128903
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- dog-1
- Danio rerio
- brip1
- Mus musculus
- Brip1
- Rattus norvegicus
- Brip1
- Saccharomyces cerevisiae
- CHL1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as CHL1
- CellAge gene expression
- This gene is present as BRIP1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs4988357
- Reference