LongevityMap Gene

Gene details

HGNC symbol: APOA4
Aliases
Common name: apolipoprotein A4
Description: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 11q23.3
UCSC Genome Browser: View 11q23.3 on the UCSC genome browser
OMIM: 107690
Ensembl: ENSG00000110244
UniProt/Swiss-Prot
Entrez Gene: 337
UniGene: 1247
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: apoa4b.2
Danio rerio: apoa4b.3
Danio rerio: apoa4a
Danio rerio: apoa4b.1
Mus musculus: Apoa4
Rattus norvegicus: Apoa4

Studies (3)

Significant/Non-significant: 1/2

Study 1

Longevity Association

Non-significant

Population

Study Design

Glutamine (CAG) to histidine (CAT) substitution at codon 360 was examined in 120 Alzheimer patients (88 females, 32 males) and 119 presumed-healthy elderly subjects (62 females, 57 males)

Conclusions

The frequency of apoAIV alleles was not significantly different between Alzheimer patients and the elderly control group. However, in both groups, apoAIV (360:His) allele frequency was higher than in the general population.

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Italian (Southern)

Study Design

APOA4-HincII-RFLP (Asp127/Ser127) polymorphism was examined in a healthy population with 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years)

Conclusions

No significant differences relative to longevity were found

Indentifier

APOA4-HincII-RFLP

Reference

Study 3

Longevity Association

Population

Study Design

Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years)

Conclusions

The Hinf347 genotype distribution was significantly different in centenarians

Indentifier

Reference