LongevityMap Gene
Gene details
- HGNC symbol
- ALPK1
- Aliases
- LAK; 8430410J10Rik
- Common name
- alpha kinase 1
- Description
- This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- Cytogenetic Location
- 4q25
- UCSC Genome Browser
- View 4q25 on the UCSC genome browser
- OMIM
- 607347
- Ensembl
- ENSG00000073331
- UniProt/Swiss-Prot
- ALPK1_HUMAN
- Entrez Gene
- 80216
- UniGene
- 652825
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
- Conclusions
- Although no genome-wide associations were significant, mutiple SNPs and genes had suggestive associations with both age at death and morbidity-free survival at age 65 years
- Indentifier
- rs10488907
- Reference