LongevityMap Gene
Gene details
- HGNC symbol
- ALDH2
- Aliases
- ALDM; ALDHI; ALDH-E2
- Common name
- aldehyde dehydrogenase 2 family (mitochondrial)
- Description
- This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
- Cytogenetic Location
- 12q24.12
- UCSC Genome Browser
- View 12q24.12 on the UCSC genome browser
- OMIM
- 100650
- Ensembl
- ENSG00000111275
- UniProt/Swiss-Prot
- ALDH2_HUMAN
- Entrez Gene
- 217
- UniGene
- 604551
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- alh-2
- Caenorhabditis elegans
- alh-1
- Danio rerio
- CABZ01032488.1
- Danio rerio
- aldh2.2
- Danio rerio
- aldh2.1
- Drosophila melanogaster
- Aldh
- Mus musculus
- Aldh2
- Rattus norvegicus
- Aldh2
- Saccharomyces cerevisiae
- ALD6
- Saccharomyces cerevisiae
- ALD4
In other databases
- GenAge model organism genes
- GenAge microarray genes
- This gene is present as ALDH2
- CellAge
- This gene is present as ALDH2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
- Indentifier
- rs671
- Reference