LongevityMap Gene
Gene details
- HGNC symbol
- AKAP10
- Aliases
- PRKA10; AKAP-10; D-AKAP2; D-AKAP-2
- Common name
- A-kinase anchoring protein 10
- Description
- This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
- Cytogenetic Location
- 17p11.2
- UCSC Genome Browser
- View 17p11.2 on the UCSC genome browser
- OMIM
- 604694
- Ensembl
- ENSG00000108599
- UniProt/Swiss-Prot
- A0A0S2Z4Z7_HUMAN
- Entrez Gene
- 11216
- UniGene
- 642676
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rgs-5
- Danio rerio
- akap10
- Drosophila melanogaster
- pkaap
- Mus musculus
- Akap10
- Rattus norvegicus
- Akap10
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Male (n= 4766) and female (n = 6202) divided into young (18-39 years) and old (60 years) groups were examined for polymorphisms
- Conclusions
- A polymorphism that results in an amino acid change from Ile to Val showed the strongest correlation with age. The Val variant was associated with a statistically significant decrease in the length of the electrocardiogram PR interval. An A to G polymorphism in the 3'UTR of D-AKAP2 showed a significant decrease of the G allele in the older sample of both genders. Additionally, the I646V polymorphism was found to be significantly different between young and old in both males and females.
- Indentifier
- AKAP10
- Reference