LongevityMap Gene
Gene details
- HGNC symbol
- AIF1
- Aliases
- IBA1; IRT1; AIF-1; IRT-1
- Common name
- allograft inflammatory factor 1
- Description
- This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]
- Cytogenetic Location
- 6p21.33
- UCSC Genome Browser
- View 6p21.33 on the UCSC genome browser
- OMIM
- 601833
- Ensembl
- ENSG00000204472
- UniProt/Swiss-Prot
- AIF1_HUMAN
- Entrez Gene
- 199
- UniGene
- 76364
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as AIF1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs2269475
- Reference