LongevityMap Gene
Gene details
- HGNC symbol
- ADCY6
- Aliases
- AC6; LCCS8
- Common name
- adenylate cyclase 6
- Description
- This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]
- Cytogenetic Location
- 12q13.12
- UCSC Genome Browser
- View 12q13.12 on the UCSC genome browser
- OMIM
- 600294
- Ensembl
- ENSG00000174233
- UniProt/Swiss-Prot
- ADCY6_HUMAN
- Entrez Gene
- 112
- UniGene
- 525401
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- si:cabz01112025.1
- Drosophila melanogaster
- CG43373
- Mus musculus
- Adcy6
- Rattus norvegicus
- Adcy6
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Chinese
- Study Design
- A 10-year follow-up study of the Chinese longitudinal healthy longevity survey was performed consisting of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from ADRB1, ADRB2, ADCY5, ADCY6, and MAPK1 were selected and genotyped.
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs1042718 (C/A) and rs1042719 (G/C), showed a significant association with the longevity phenotype
- Indentifier
- rs2291727
- Reference