LongevityMap Gene
Gene details
- HGNC symbol
- ADCY2
- Aliases
- AC2; HBAC2
- Common name
- adenylate cyclase 2
- Description
- This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 5p15.31
- UCSC Genome Browser
- View 5p15.31 on the UCSC genome browser
- OMIM
- 103071
- Ensembl
- ENSG00000078295
- UniProt/Swiss-Prot
- ADCY2_HUMAN
- Entrez Gene
- 108
- UniGene
- 481545
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- acy-2
- Danio rerio
- adcy2b
- Danio rerio
- adcy2a
- Drosophila melanogaster
- CG32305
- Drosophila melanogaster
- ACXA
- Drosophila melanogaster
- ACXB
- Drosophila melanogaster
- CG32301
- Drosophila melanogaster
- ACXC
- Drosophila melanogaster
- Ac76E
- Drosophila melanogaster
- ACXE
- Drosophila melanogaster
- ACXD
- Mus musculus
- Adcy2
- Rattus norvegicus
- Adcy2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
- Indentifier
- rs326146
- Reference