LongevityMap Gene
Gene details
- HGNC symbol
- ADAMTS7
- Aliases
- ADAM-TS7; ADAMTS-7; ADAM-TS; 7
- Common name
- ADAM metallopeptidase with thrombospondin type 1 motif 7
- Description
- The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
- Cytogenetic Location
- 15q25.1
- UCSC Genome Browser
- View 15q25.1 on the UCSC genome browser
- OMIM
- 605009
- Ensembl
- ENSG00000136378
- UniProt/Swiss-Prot
- ATS7_HUMAN
- Entrez Gene
- 11173
- UniGene
- 16441
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
- Conclusions
- Although no genome-wide associations were significant, several SNPs in some previously associated genes with longevity had suggestive associations with age at death or morbidity-free survival at age 65 years. Noteworthy results included two SNPs within FOXO1A (rs10507486 and rs4943794) associated with age at death.
- Indentifier
- rs1383636
- Reference