LongevityMap Gene
Gene details
- HGNC symbol
- ACTR3B
- Aliases
- ARP11; ARP3BETA
- Common name
- ARP3 actin related protein 3 homolog B
- Description
- This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
- Cytogenetic Location
- 7q36.1-q36.2
- UCSC Genome Browser
- View 7q36.1-q36.2 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000133627
- UniProt/Swiss-Prot
- ARP3B_HUMAN
- Entrez Gene
- 57180
- UniGene
- 647117
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- arx-1
- Danio rerio
- actr3b
- Drosophila melanogaster
- Arp3
- Mus musculus
- Actr3b
- Rattus norvegicus
- Actr3b
- Saccharomyces cerevisiae
- ARP3
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs4574762
- Reference