LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Finnish
- Study Design
- 250 (52 males and 198 females) nonagenarians and 400 healthy control group (18-60 years old) were examined for -174, +3953 and -511 SNPs
- Conclusions
- No significant differences relative to longevity were found
- Identifier
- IL6
- Cytogenetic Location
- 7p15.3
- UCSC Genome Browser
- View 7p15.3 on the UCSC genome browser
Gene details
- HGNC symbol
- IL6
- Aliases
- CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
- Common name
- interleukin 6
- Description
- This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- Other longevity studies of this gene
- 19
- OMIM
- 147620
- Ensembl
- ENSG00000136244
- UniProt/Swiss-Prot
- B4DNQ5_HUMAN
- Entrez Gene
- 3569
- UniGene
- 654458
- HapMap
- View on HapMap