LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- 401C/T SNP was examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old)
- Conclusions
- No significant difference in genotypic frequencies was found between centenarians and controls
- HGNC symbol
- SOD2
- Aliases
- IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
- Common name
- superoxide dismutase 2
- Description
- This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
- Other longevity studies of this gene
- 21
- OMIM
- 147460
- Ensembl
- ENSG00000112096
- UniProt/Swiss-Prot
- A0A0C4DFU1_HUMAN
- Entrez Gene
- 6648
- UniGene
- 487046
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sod-2
- Caenorhabditis elegans
- sod-3
- Danio rerio
- sod2
- Drosophila melanogaster
- Sod2
- Mus musculus
- Sod2
- Rattus norvegicus
- Sod2
- Saccharomyces cerevisiae
- SOD2
- Schizosaccharomyces pombe
- SPBC16A3.14
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- A homolog of this gene for Drosophila melanogaster is present as Sod2
- A homolog of this gene for Mus musculus is present as Sod2
- A homolog of this gene for Caenorhabditis elegans is present as sod-2
- GenAge human genes
- This gene is present as SOD2
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- CellAge
- This gene is present as SOD2
De Benedictis et al. (1998)
Other variants which are also part of this study
