LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- The TH01 short tandem repeat polymorphism was studied for longevity association in 471 long-lived individuals (96-110 years) and 462 younger controls (19-75 years) from Germany
- Conclusions
- No association between TH01 and longevity was observed
- Identifier
- TH01
- Cytogenetic Location
- 11p15.5
- UCSC Genome Browser
- View 11p15.5 on the UCSC genome browser
Gene details
- HGNC symbol
- TH
- Aliases
- TYH; DYT14; DYT5b
- Common name
- tyrosine hydroxylase
- Description
- The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 4
- OMIM
- 191290
- Ensembl
- ENSG00000180176
- UniProt/Swiss-Prot
- P78428_HUMAN
- Entrez Gene
- 7054
- UniGene
- 435609
- HapMap
- View on HapMap