LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- HGNC symbol
- MLH1
- Aliases
- FCC2; COCA2; HNPCC; hMLH1; HNPCC2
- Common name
- mutL homolog 1
- Description
- This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]
- Other longevity studies of this gene
- 8
- OMIM
- 120436
- Ensembl
- ENSG00000076242
- UniProt/Swiss-Prot
- A0A024R2S9_HUMAN
- Entrez Gene
- 4292
- UniGene
- 195364
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- mlh-1
- Danio rerio
- mlh1
- Drosophila melanogaster
- Mlh1
- Mus musculus
- Mlh1
- Rattus norvegicus
- Mlh1
- Saccharomyces cerevisiae
- MLH1
- Schizosaccharomyces pombe
- mlh1
- GenAge human genes
- This gene is present as MLH1
Debrabant et al. (2014)
Other variants which are also part of this study
