LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- HGNC symbol
- POLB
- Aliases
-
- Common name
- DNA polymerase beta
- Description
- The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
- Other longevity studies of this gene
- 3
- OMIM
- 174760
- Ensembl
- ENSG00000070501
- UniProt/Swiss-Prot
- B7Z1W5_HUMAN
- Entrez Gene
- 5423
- UniGene
- 654484
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- polb
- Mus musculus
- Polb
- Rattus norvegicus
- Polb
- GenAge human genes
- This gene is present as POLB
Debrabant et al. (2014)
Other variants which are also part of this study
