LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Danish
Study Design
38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
Conclusions
No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
Identifier
rs2284659
In Other Studies (IDs)
2702
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser

Gene details

HGNC symbol
SOD3
Aliases
EC-SOD 
Common name
superoxide dismutase 3 
Description
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Other longevity studies of this gene
16
OMIM
185490
Ensembl
ENSG00000109610
UniProt/Swiss-Prot
A0A140VJU8_HUMAN
Entrez Gene
6649
UniGene
2420
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
sod3b
Drosophila melanogaster
Sod3
Mus musculus
Sod3
Rattus norvegicus
Sod3
Saccharomyces cerevisiae
SOD1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
  • A homolog of this gene for Mus musculus is present as SOD3
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1

References

Dato et al. (2014)

Other variants which are also part of this study