LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Danish
Study Design
38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
Conclusions
No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
Identifier
rs2375005
In Other Studies (IDs)
2101
Cytogenetic Location
7q21.3
UCSC Genome Browser
View 7q21.3 on the UCSC genome browser

Gene details

HGNC symbol
PON2
Aliases
 
Common name
paraoxonase 2 
Description
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
14
OMIM
602447
Ensembl
ENSG00000105854
UniProt/Swiss-Prot
A0A0J9YYG4_HUMAN
Entrez Gene
5445
UniGene
514420
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
poml-2
Caenorhabditis elegans
poml-4
Caenorhabditis elegans
poml-3
Caenorhabditis elegans
mec-6
Danio rerio
pon3.2
Danio rerio
pon3.2
Danio rerio
pon2
Danio rerio
pon1
Mus musculus
Pon2
Rattus norvegicus
Pon2

References

Dato et al. (2014)

Other variants which are also part of this study